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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Stroke. 2017 Jan 5;48(2):445–451. doi: 10.1161/STROKEAHA.116.014790

Figure 3.

Figure 3

A, Following warfarin pretreatment, then 2h of MCAO and tPA infusion 1h later, i.p. ML351 delivered concomitantly reduced hemoglobin levels in the ipsilateral side of the brain at 24h (*p<0.05). B, Hemorrhage in brain sections was significantly reduced by treatment with ML351 (*p<0.05; n=5 for vehicle, n=7 for ML351). C, 12/15-LOX protein, detected by immunohistochemistry, was increased in the brains of warfarin-pretreated mice (***p<0.001, *p<0.05 compared to MCAO only; n=3/group, 24 images/brain) following MCAO. D, Representative images show that most of the increased 12/15-LOX signal following warfarin treatment is vessel-derived (Scale Bar = 100 µm).