Fig. 1.

The effect of L-AAA and Lu AA33810 administered alone or in combination on the immobility (a), climbing (b), and swimming time (c) in the FST in rats. L-AAA was administered twice into the rat mPFC at a dose of 100 μg/2 μl, on the first and second day of the experiment and the FST was performed 72 h after the second toxin injection. Lu AA33810, 10 mg/kg, i.p., was given 60 min before the FST. The obtained data were presented as the means ± SEM (n = 6–14 rats per group) and evaluated by two-way ANOVA followed by the Newman-Keuls multiple comparison test. *p < 0.05 vs. control; ^## p < 0.01 vs. L-AAA-treated group