Fig. 2.

The effects of MAPK/ERK and PI3K inhibitors on the antidepressant-like effect of Lu AA33810 in the FST in rats. Pretreatment with U0126 (5 μg/2 μl/rat, i.c.v.), an MAPK/ERK inhibitor (a) and LY294002 (10 nmol/2 μl/rat, i.c.v.) a PI3K inhibitor (b) 75 min before the test prevented the anti-immobility effect of Lu AA33810 treatment (10 mg/kg, i.p., 60 min before the test) in the FST in rats. The obtained data were presented as the means ± SEM (n = 6–9 rats per group) and evaluated by two-way ANOVA, followed by the Newman-Keuls multiple comparison test. *p < 0.05 vs. control; ^# p < 0.05 vs. Lu AA33810 treated group