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M1T1 GAS strain 5448 preferentially adheres to and invades H-antigen-expressing HBE cells via the M1 protein B repeat domains. (a) Adherence and (b) invasion of HBE cells by M1T1 GAS strains 5448 and 5448M1* in the presence and absence of 100 μM M1 B repeat fragment. Data are representative of three independent experiments performed in triplicate. Adherent and internalized bacteria were normalized to the inoculum.
