Figure 3.

Rising cAMP Levels Produce GluA3-Dependent Postsynaptic Potentiation

(A) Wash-in of 50 μM FSK causes synaptic potentiation at WT PCs (black) and GluA1-KO PCs (red), but not at GluA3-KO PCs (blue). Top, middle, and bottom show example traces, normalized EPSC amplitude, and paired pulsed ratio (PPR), respectively.

(B) Enhancement of currents evoked by local puffs of 1 μM AMPA at the molecular layer following FSK application can also occur in the presence of TTX-blocking PF input.

Error bars indicate SEM; ^∗ indicates p < 0.05.