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. 2004 Oct 15;5:38. doi: 10.1186/1471-2121-5-38

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Copyright © 2004 Rawlings et al; licensee BioMed Central Ltd.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Socs44A misexpression reduces JAK signaling in the wing. Wild-type venation (A) is compared with a viable hop mutant, hop^msv/hop^M38(B). hop reduction causes ectopic vein (arrow) near the posterior crossvein. (C) Expression of UAS-Socs36E using the engrailed-GAL4 driver (e16E-GAL) produces a similar ectopic vein phenotype, plus the loss of the anterior crossvein (arrowhead). (D) Similar misexpression of Socs44A causes ectopic wing vein production near the posterior crossvein (arrow) and arching of vein L3 (arrowhead). (E) Reduction of the dosage of hop enhances the Socs44A misexpression phenotype. (F) Misexpression of hop in the posterior compartment causes dramatic vein loss, but that loss is restored by the simultaneous expression of Socs44A (G).