Table 1.
Demographics of end-stage renal disease dialysis (ESRD) patients with and without new cancer, and results of a multivariate analysis of cancer risks.
| ESRD patients on maintenance dialysis, N (%) = 40,833 (100%) | |||
|---|---|---|---|
| Without new cancer 38481 (94.2%) | With new cancer 2352 (5.8%) | Multivariate Analysis Adjusted HR (95% CI) | |
| Age at first dialysis (years) | |||
| < 35 | 2280 (97.6) | 55 (2.4) | Reference |
| 35-64 | 21146 (93.8) | 1397 (6.2) | 3.42 (2.60-4.48)** |
| ≥ 65 | 15055 (94.4) | 900 (5.6) | 4.73 (3.59-6.25)** |
| Age at cancer diagnosed (years) | 63.0 ± 10.1* | ||
| Mean time from dialysis to cancer (months) | 41.3 ± 26.6* | ||
| Median time from dialysis to cancer (months) | 37.37 (25th-75th percentile, 19.37 - 58.19) | ||
| Gender | |||
| Female | 20211 (94.2) | 1232 (5.8) | Reference |
| Male | 18270 (94.3) | 1120 (5.7) | 1.10 (1.02-1.20)** |
| Initial dialysis modality | |||
| Hemodialysis | 34890 (95.5) | 2181 (4.5) | Reference |
| Peritoneal dialysis | 3577 (94.1) | 170 (5.9)# | 0.88 (0.75-1.21) |
| Comorbidity | |||
| Diabetes mellitus | |||
| no | 19616 (92.7) | 1534 (7.3)# | Reference |
| yes | 18865 (95.8) | 818 (4.2) | 0.74 (0.67-0.81)** |
| Hypertension | |||
| no | 8173 (91.7) | 735 (8.3)# | Reference |
| yes | 30310 (94.9) | 1617 (5.1) | 0.69 (0.63-0.76)** |
| Cardiovascular disease | |||
| no | 22810 (93.3) | 1633 (6.7)# | Reference |
| yes | 15671 (95.6) | 719 (4.4) | 0.89 (0.81-0.98)** |
| Chronic lung disease | |||
| no | 34479 (94.2) | 2138 (5.8) | Reference |
| yes | 4002 (94.9) | 214 (5.1) | 1.03(0.89-1.19) |
| Chronic liver disease | |||
| no | 35474 (94.5) | 2070 (5.5)# | Reference |
| yes | 3007 (91.4) | 282 (8.6) | 1.76 (1.55-1.99)** |
| Congenital renal and urinary tract disease | |||
| no | 37679 (94.2) | 2320 (5.8) | Reference |
| yes | 802 (96.2) | 32 (3.8) | 0.77 (0.68-1.23) |
*Data are means ± standard deviation (SD).
#P < 0.001 between “yes” and “no” indicate comorbidity in patients with new cancer.
**Significantly different.