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. 2017 Jan 1;8(1):65–73. doi: 10.7150/jca.16739

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© Ivyspring International Publisher. This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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Notch protein domains and the canonical Notch signal transduction pathway. (A) Diagrammatic representation of the domains of the Drosophila Notch (dNotch) receptor and the four known mammalian receptors. Note that Notch3 and Notch4 contain no transcriptional activation domain TAD domain. PM, plasma membrane; EGFLR, epidermal growth-factor-like repeats; ANK, Ankyrin/CDC10 repeats; NLS, nuclear localization signals; TAD, transcriptional activation domain; PEST, Pro Glu Ser Thr (PEST) sequence. (B) Notch does not directly bind to DNA. In the canonical Notch signal transduction model, Notch does not directly bind to DNA, rather goes through CSL. In the absence of Notch intracellular domain (NICD), CSL binds to co-repressors. The interaction CSL with ANK repeats of the NICD displace these repressors to generate a transcriptional activator complex.