Table 1.
Top 10 KEGG pathways relevant to CHIP-Seq-based Notch1, Notch2 and CSL target genes.
| Pathways (gene numbers) | |||
|---|---|---|---|
| Rank | Notch1 target genes | Notch2 target genes | CSL target genes |
| 1 | PI3K-Akt signaling pathway (15) | PI3K-Akt signaling pathway (16) | Regulation of actin cytoskeleton (4) |
| 2 | Transcriptional misregulation in cancer (10) | Pathways in cancer (13) | PI3K-Akt signaling pathway (4) |
| 3 | Metabolic pathways (10) | Transcriptional misregulation in cancer (10) | cAMP signaling pathway (3) |
| 4 | Pathways in cancer (9) | Viral carcinogenesis (9) | Tight junction (2) |
| 5 | Ras signaling pathway (9) | cAMP signaling pathway (9) | Arrhythmogenic right ventricular cardiomyopathy (ARVC) (2) |
| 6 | MAPK signaling pathway (9) | Metabolic pathways (9) | Calcium signaling pathway (2) |
| 7 | Proteoglycans in cancer (9) | HTLV-I infection (9) | Jak-STAT signaling pathway (2) |
| 8 | Regulation of actin cytoskeleton (8) | Neuroactive ligand-receptor interaction (9) | Hypertrophic cardiomyopathy (HCM) (2) |
| 9 | HTLV-I infection (8) | Ras signaling pathway (8) | Herpes simplex infection (2) |
| 10 | MicroRNAs in cancer (7) | Epstein-Barr virus infection (7) | MicroRNAs in cancer (2) |
Notes: By importing Entrez Gene IDs of ChIP-Seq-based Notch1, Notch2 and CSL target genes into the Functional Annotation tool of KEGG, KEGG pathways showing significant relevance to the set of imported genes were identified.