Table 1.
Sensitivity of prostate-derived cell lines to NMS-P645, analyzed by tritiated thymidine-incorporation assay. IC50 values (mean ± SD) are reported.
| Cell line | Cell type (known genetic alterations) | IC50 [μM] |
|---|---|---|
| VCaP | PCa (TMPRSS2/ERG) | 2.7 ± 1.1 |
| 22Rv1 | PCa | 5.2 ± 1.1 |
| DU-145 | PCa (UBE2L3/KRAS) | 9.7± 1.0 |
| LNCaP | PCa (MIPOL1/ETV1) | 5.4 ± 1.1 |
| BPH1 | Benign Prostate Hyperplasia | 4.9 ± 1.1 |
| RWPE1 | Normal Prostate Epithelium | 4.2 ± 1.2 |
| RWPE1-Empty | Stable Transfectant (empty vector) | 4.5 ± 1.2 |
| RWPE1-tERG | Stable Transfectant (TMPRSS2/ERG) | 4.0 ± 1.1 |
| RWPE1-PIM1 | Stable Transfectant (PIM1) | 3.5 ± 1.2 |