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Combination Indexes obtained in prostate cancer (VCaP and 22Rv1) and non-cancerous (RWPE-1) cell lines by NMS-P645/GDC-0941 simultaneous treatment. Graded symbols represent the average CI and are derived from the original publication 25.
| Cell line | Ratio | Combination Index (CI) at | Grade Synergism | ||
|---|---|---|---|---|---|
| ED50 | ED75 | ED90 | |||
| VCaP | 1:10 | 0.846 | 0.726 | 0.661 | ++ |
| 22Rv1 | 1:10 | 0.484 | 0.543 | 0.610 | +++ |
| RWPE-1 | 1:10 | 1.282 | 1.454 | 1.668 | - - - |
