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. 2016 Sep 14;21(2):208–221. doi: 10.1111/jcmm.12957

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© 2016 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Alternol inhibits the growth of OS in vivo (A) Flow diagram of in vivo nude mouse tibia orthotopic model establishment and treatment plan. (B and C) Body weight and tumour size were measured every 3 days. (D) Macroscopic appearance of tibia primary osteosarcoma tumours in BABL/c nude mice after treatment with alternol or vehicle. (E and F) The expression of cleaved caspase‐3, phosph‐JNK, phosph‐STAT3 were examined by immunohistochemistry using tibia tumour samples slides. *P < 0.05 versus with vehicle control, **P < 0.01 versus with vehicle control.