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Histopathological and histochemical studies. (A–C) Skeletal muscle biopsy from P2; (D–F) postmortem cardiac tissue from P16; (G–I) postmortem kidney tissue from P16. Marked c oxidase (COX)-deficient muscle fibres (c) and renal tubules (i), lesser extent of COX deficiency in cardiomyocytes was identified through sequential COX/succinate dehydrogenase (SDH) histochemical reaction.
