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. 2016 May 4;76(1):218–226. doi: 10.1136/annrheumdis-2015-208577

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Lubricin was upregulated following destabilisation of the medial meniscus (DMM). Wild-type (WT) and wnt16^−/− mice were subjected to DMM and killed 2 days thereafter. (A) The joint surface, including the articular cartilage and the subchondral bone, was dissected and processed for gene expression analysis by real-time PCR. Lubricin was upregulated in WT mice but not in wnt16^−/− mutants at mRNA level 2 days following DMM (N≥10). (B) At protein level, lubricin staining following DMM was detected in the superficial layer of the articular cartilage and in a region between the intermediate and the deep layer in WT mice. (C) The area of the articular cartilage positive for lubricin staining 2 days following DMM was significantly higher in WT mice (N=4) than in wnt16^−/− mice (N=6). (D) WNT16 recombinant protein upregulated lubricin mRNA expression in bovine articular chondrocyte (BAC) at 24 h (N=3). KO, knockout. *p<0.05; **p<0.01; ***p<0.001.