Effects of PK2 knockdown or over-expression on cytokines in mouse model. Cytokines of INF-γ (a), IL-2 (b), IL-12 (c), IL-22 (d), IL-23 (e), TNF-α (f), IL-1α (g), IL-1β (h), and IL-17(i) in blood. C: control, NaCl (0.9%) solution; NS: negative control of sh-PK2, retrovirus of psh-Scr; S: sh-PK2, retrovirus of psh-PK2; NP: negative control of PLVX-PK2, the lentivirus of empty PLVX-puro; P: PLVX-PK2, the lentivirus of PK2-PLVX-puro. All the bars and line graphs represent the average of three independent experiments ± SD for five mice in each group. Significant statistics difference indicated by asterisks (*, P < 0.05; **, P < 0.01) versus control at each time point.