Table 2.
Demographics of alcoholics and control subjects from New South Wales Brain Tissue Bank
| DSM V alcohol classification | Age | PMI | Brain pH | RIN | Lifetime alcohol (kg) | Cause of death | Agonal state/mode of death |
|---|---|---|---|---|---|---|---|
| Control | 24 | 43 | 6.27 | 6.2 | 15 | Arrhythmia | Rapid |
| Control | 40 | 27 | 6.79 | 7.4 | 47 | Pulmonary embolus | Intermediate |
| Control | 44 | 50 | 6.6 | 7.1 | 28 | IHD | Rapid |
| Control | 46 | 29 | 6.12 | 4.4 | 115 | MI | Intermediate |
| Control | 48 | 24 | 6.73 | 6.9 | 17 | IHD | Rapid |
| Control | 50 | 30 | 6.37 | 7.5 | 0 | IHD | Rapid |
| Control | 50 | 40 | 6.87 | 8.6 | 18 | Hemopericardium | Rapid |
| Control | 53 | 16 | 6.84 | 7.9 | 102 | Cardiomyopathy | Rapid |
| Control | 60 | 28 | 6.8 | 8 | 0 | IHD | Rapid |
| Control | 62 | 46 | 6.95 | 8.8 | 5 | IHD | Rapid |
| Mean ± SEM | 48 ± 3 | 33 ± 3 | 6.56 ± 0.1 | 7.28 ± 1 | 35 ± 13 | ||
| AUD, mild | 25 | 43.5 | 6.7 | 6.9 | 552 | CO and EtOH | Intermediate |
| AUD, moderate | 42 | 41 | 6.5 | 8 | 1472 | Bromoxynil/EtOH | Intermediate |
| AUD, remission | 44 | 15 | 6.48 | 7.9 | 639 | IHD | Rapid |
| AUD, severe | 45 | 18.5 | 6.57 | 7.9 | 1799 | Drowning | Intermediate |
| AUD, severe | 49 | 44 | 6.41 | 6.4 | 1012 | IHD | Rapid |
| AUD, severe | 49 | 16 | 6.19 | 6.2 | 613 | MI | Rapid |
| AUD, moderate | 50 | 17 | 6.3 | 7.0 | 2453 | IHD | Rapid |
| AUD, severe | 50 | 34.5 | 6.93 | 7.3 | 5212 | Acute bronchitis | Intermediate |
| AUD, severe | 61 | 59 | 6.57 | 6.1 | 8052 | Myocarditis | Intermediate |
| AUD, severe | 61 | 23.5 | 6.92 | 8.3 | 5621 | IHD | Rapid |
| Mean ± SEM | 48 ± 3 | 31 ± 5 | 6.63 ± 0.1 | 7.2 ± 1 | 2743 ± 829 |
Detailed clinical data was collected for each subject as described in the “Methods” section. All subjects were male. AUD alcohol use disorder, PMI postmortem interval, IHD ischemic heart disease, MI myocardial infarction, CO carbon monoxide. Agonal state terminal phase durations—rapid: <1 h, intermediate: 1–24 h, long term >24 h