Fig. 2.
Electrophysiological analyses of WT and mutant Cav3.2 channels. A. Representative families of Cav3.2 WT and Cav3.21549Ile currents elicited by a series of depolarization steps ranging from − 80 to + 30 mV from a HP of − 100 mV. The dotted line indicates the zero current level. B. Current-voltage (I–V) relationship obtained from experiments as illustrated in panel A for Cav3.2 WT and mutant Cav3.2 channels. C–D. Activation kinetics (C) and inactivation kinetics (D) as a function of the potential for Cav3.2 WT and mutant Cav3.2 channels.