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. 2017 Jan 25;7:40989. doi: 10.1038/srep40989

Figure 7. Specificity of detection is maintained with one time dosing of DIR-RGD-NP.

Figure 7

(A) Upon establishment of tumors (ROI~40,000), mice were given a single dose of DIR-RGD-NP (“higher dose” indicated in Table 1; n = 4). Stereoscopic images show detection of micrometastasis by white light. White arrows point to micrometastasis. M, mesentery; I, instestines. (B) i, Ex vivo imaging and colocalization of mCherry and DIR signals in dissected tumors; ii, quantification of DIR intensity and penetration in cross-sectioned tumors.