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. 2016 Oct 19;13:113–124. doi: 10.1016/j.ebiom.2016.10.026

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — H19 regulates CDK8 transcription levels. (a) Predicted functional change of CTNNB1 and MED1. (b)H19 on CDK8 levels. (c) Venn diagram of overlapping genes regulated > 2 fold in HCT116 cells by siRNAs against each of CTNNB1, H19, and CDK8.(d) Heat map representation of Log2 transformed fold changes of overlapping genes. (e) CDK8 effect on overlapping genes in HCT116 cells. (f) CDK8 effect on cell proliferation. The statistical significance between groups was determined using 2-way ANOVA analysis with GraphPad software. * P < 0.05. See also Fig. S5.