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. 2016 Oct 19;13:113–124. doi: 10.1016/j.ebiom.2016.10.026

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© 2016 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 7 — Clinical significance of H19 and its molecular targets in CRC. (a) Expression correlation of H19 and CSRP2, and their association with overall survival (OS) in TCGA CRC dataset. (b) Enrichment analysis of genes showing significantly inverse expression correlation with H19 in TCGA CRC dataset. Genes with spearman's rank correlation coefficient less or equal to − 0.25 were analyzed using Enrichr at http://amp.pharm.mssm.edu/Enrichr/. (c) Genes showing inverse correlation with H19 in both TCGA CRC data and microarray data were subject to enrichment analysis using Enrichr. To maximize the overlapping genes, we used genes with spearman's rank correlation coefficient ≤− 0.15 in TCGA dataset, and used the microarray data of HCT116 si-H19-2. (d) Genes showing positive correlation with H19 in both TCGA data and microarray data were subject to enrichment analysis using Enrichr. To maximize the overlapping genes, we used genes with spearman's rank correlation coefficient ≥ 0.15 in TCGA dataset. See also Fig. S7 and Table S2.