Fig. 8.

The expression of TSP-2 is correlated with Gleason score of PCa and MMP-2 expression. The expression of TSP-2 (a) and miR-376c (b) between healthy individuals and PCa patients was determined from 52 cases of The Cancer Genome Atlas (TCGA) database. The correlation of TSP-2 (c) and MMP-2 (d) with PCa progression was determined from 45, 245, 63, 136, and 3 individuals of PCa patients from the Gleason score 6~10 of TCGA database. The one-way ANOVA with Bonferroni’s multiple comparisons test was performed, and p ≤ 0.05 showed significance. e The correlation gene expression between TSP-2 and MMP-2 was illustrated from 493 cases of TCGA database. f The working model represents the roles of TSP-2 on skeletal metastasis of PCa