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. 2017 Jan 25;15:16. doi: 10.1186/s12916-017-0793-9

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Structural MRI of canine brains. Coronal MRI scans (1.5 Tesla) of 4-, 9-, and 15-year-old dogs, taken from locations at the level of thalamus (upper row) and hippocampus (lower row). Older animals show marked increase in ventricular volume (black arrows) and cortical atrophy, with deep gyri and widened sulci (white arrows). Three-dimensional images across the whole brain were acquired using a spoiled gradient recall (SPGR) sequence to obtain detailed anatomic images. Modified from [129] with permission