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. Author manuscript; available in PMC: 2017 Jan 25.
Published in final edited form as: Neuropharmacology. 2016 Mar 10;107:18–26. doi: 10.1016/j.neuropharm.2016.03.018

Fig. 2. Lactulose prevents Meth-induced decreases in tight junction proteins of the BBB.

Fig. 2

Rats were pretreated with lactulose or vehicle for 2 days before treatment with Meth or saline. A) Occludin and B) claudin-5 were measured via Western Blot in isolated capillaries from cortical tissue, 24 h after Meth or saline treatment. Meth treatment significantly decreased occludin (*, p < 0.005, compared to Vehicle Saline) and claudin-5 (*, p < 0.001, compared to Vehicle Saline) protein expression, which was blocked by lactulose pretreatment (#, p < 0.001, compared to Vehicle Meth) (n = 6–13 per group). C) Representative Western Blot image of occludin, claudin-5 and α-tubulin.