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. Author manuscript; available in PMC: 2017 Jan 25.
Published in final edited form as: Neuropharmacology. 2016 Mar 10;107:18–26. doi: 10.1016/j.neuropharm.2016.03.018

Fig. 3. Lactulose prevents Meth-induced increases in FITC-dextran extravasation.

Fig. 3

Rats were pretreated with lactulose or vehicle for 2 days before treatment with Meth or saline. Rats were intracardially perfused with 10,000 Da FITC-dextran, 24 h after Meth or saline treatment. A) Representative 20X confocal images of FITC-dextran in cortical sections. B) Quantification of FITC-dextran indicates that Meth treatment significantly increased FITC-dextran extravasation (*, p < 0.05, compared to Vehicle Saline), which was blocked by lactulose pretreatment (#, p < 0.05, compared to Vehicle Meth) (n = 4–5 per group).