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. Author manuscript; available in PMC: 2017 Jan 25.
Published in final edited form as: Ann Surg. 2015 Sep;262(3):519–525. doi: 10.1097/SLA.0000000000001420

TABLE 3.

Histologic Characteristics by Mutation

BRAF V600E RAS RET/PTC PAX8-PPARγ BRAFK601E
Mean tumor size, cm 1.7 ± 1.2 2.3 ± 1.6 2 ± 1.5 3.2 ± 1.6 2.4 ± 3.1
Multifocal 360 (56%) 153 (47%) 23 (63%) 7 (44%) 9 (75%)
Extrathyroidal extension 327 (51%) 15 (4.6%) 18 (49%) 0 0
No. with CLND 523 (81%) 156 (48%) 33 (89%) 8 (50%) 7 (58%)
CLNM 286 (55%) 16 (10%) 23 (70%) 0 0
LLNM 92 (14%) 4 (1.2%) 13 (35%) 0 0
Distant metastasis at presentation 13 (2%) 7 (2%) 3 (8%) 0 0
TNM stage
  1 56% 67% 57% 69% 100%
  2 4% 15% 8% 13% 0%
  3 32% 13% 22% 19% 0%
  4 9% 3% 14% 0% 0%

CLND indicates Central compartment lymph node dissection.