Table 1.
Demographics and characteristics of subjects at baseline. Note: FEV1 forced expiratory volume in 1 s; FVC forced vital capacity; PS pancreatic sufficiency; PPI Proton Pump Inhibitor; H2RA Histamine 2 receptor agonist; – no PPI or H2RA; NMD no mutation detected.
| Subject | Sex | Age (years) | PS | Acid suppression | Genotype |
|---|---|---|---|---|---|
| 1 | F | 20 | Yes | PPI | G551D/P67L |
| 2 | M | 22 | No | PPI | G551D/F508del |
| 3 | F | 21 | No | – | G551D/G542X |
| 4 | F | 21 | No | – | G551D/F508del |
| 5 | F | 17 | No | PPI | G551D/F508del |
| 6 | F | 38 | No | H2RA | G551D/F508del |
| 7 | F | 20 | No | PPI | G551D/F508del |
| 8 | M | 23 | No | PPI | G551D/F508del |
| 9 | M | 25 | No | H2RA | G551D/F508del |
| 10 | M | 28 | No | PPI | G551D/F508del |
| 11 | M | 24 | No | PPI | G551D/F508del |
| 12 | M | 28 | No | – | G551D/W401X |
| Median (range) |
24 17–38 |
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