Table 4. Comparison of mycobacterial SDR protein and cofactor surface area with other NAD- and NADP-dependent dehydrogenases.

Species	PDB ID	Protein surface area (A2)	Cofactor total surface area (A2)	Cofactor solvent accessible surface area (A2)
M. abscessus	3S55	11,341	839	12
M. avium	3T7C	12,365	839	21
M. avium	3UVE	12,334	834	28
M. avium	4RGB	11,338	842	7
M. avium	3PXX	11,686	841	14
M. avium	5EJ2	11,728	852	26
M. paratuberculosis	3PGX	11,168	835	19
M. paratuberculosis	3SX2	11,320	842	7
M. paratuberculosis	3TSC	11,472	840	26
Average mycobacterial SDRs		11,639	840	18
Acholeplasma laidlawii	4NBT	10,890	842	99
Xanthobacter autotrophicus	4ITU	10,608	849	64
Homo sapiens	4CQM	11,373	837	72
Helicobactor pylori	4IIN	10,545	836	160
Bacillus sp. Sg-1	4NBU	11,127	840	48
Average NAD-bound dehydrogenases		11,015	841	89
Staphylococcus aureus	3SJ7	11,371	928	106
Listeria monocytogenes	4JRO	11,057	902	103
Synechococcus elongatus	4DMM	10,985	927	64
Brassica napus	1EDO	10,757	911	64
Escherichia coli	4IIU	11,223	916	74
Average NADP-bound dehydrogenases		11,079	916	82