Fig. 3.
Over-expression of miR-9 in glioma cells increases cell invasion at low plating densities, and decreased cell invasion and migration at high densities. a Invasion of 9 L, 9 L–m9, U87, or U87-m9 cells in matrigel invasion chamber assays. 9 L–m9 and U87-m9 cells invaded more at 5000 cells/cm2, and invaded less at 50000 cells/cm2 compared to 9 L or U87 control, respectively. *p < 0.05, **p < 0.01 vs. control. b Tumor spheroid migration assay with 9 L or 9 L–m9 cells imaged at 96 h. Radial cell migration away from the tumor spheroid was higher in 9 L cells compared to 9 L–m9 cells (956.0 ± 84.0 μm vs. 433.3 ± 155.0 μm, **p < 0.01)