Fig. 1.

Iron-related proteins in invasive breast carcinomas according to HFE genotype. a Representative images of Hepcidin, FPN1, TfR1 and FT immunostaining in invasive breast carcinomas. b Median hepcidin, FPN1, TfR1 and FT expression, in epithelial cells, lymphocytes and macrophages from invasive breast carcinomas, in relation to the presence or absence (WT) of the p.His63Asp and p.His63Asp variants in IDC patients. Cell types were discriminated based on their morphology. Scores ranged from 0 to 15 and errors bars present 95% CI. Abbreviations: WT Wild-Type, FPN1 ferroportin 1, TfR1 transferrin receptor 1, FT ferritin, IDC Invasive Ductal Carcinoma