Table 7.

Results of the Analysis of the NIDDM1 Data Set^[Note]

					P Value for Our Test
MapOrder	Locus	AlleleFrequency	No. ofFamilies	LinkageP Value	Unadjusted	Adjusted (7.4×10-4)
1	SNP20	.85	153	3.57×10-5	.0001337	.0394
2	SNP66	.88	124	5.95×10-5	.0009932	.1048
3	SNP45	.94	163	1.58×10-5	.0001234	.0285
4	SNP44	.94	164	2.32×10-5	.0001009	.0376
5	SNP43a	.73	160	2.01×10-5	.0000001	.0004
6	SNP79	.97	161	2.66×10-5	.0000244	.0247
7	SNP78	.94	162	2.03×10-5	.0000558	.0291
8	SNP77	.92	161	1.58×10-5	.0000522	.0228
9	SNP56	.57	149	4.40×10-5	.0001638	.0157
10	SNP19a	.56	161	1.47×10-5	.0000347	.0042
11	SNP48	.55	154	1.64×10-5	.0000303	.0033
12	SNP62	.81	125	6.27×10-5	.0081385	.1174
13	SNP63a	.76	130	3.50×10-5	.0001566	.0197
14	SNP26	.92	162	2.04×10-5	.0000356	.0137
15	SNP25	.50	156	4.07×10-5	.0000322	.0054
16	SNP24	.98	162	1.92×10-5	.0000053	.0201
17	SNP23	.85	158	1.67×10-5	.0000556	.0084
18	SNP22	.61	158	1.56×10-5	.0019207	.0253
19	SNP53	.90	155	6.80×10-5	.0000026	.0161
20	SNP38	.62	154	5.62×10-5	.0004898	.0196
21	SNP29	.77	151	1.48×10-5	.0001107	.0074
22	SNP28	.56	156	0.46×10-5	.0003044	.0057

Note.— The SNPs are listed in map order. The number of families (i.e., the number of sibships with at least two genotyped affected sibs) varies from SNP to SNP because of missing data for some SNPs in some families. The linkage P value is the P value for the ordinary allele-sharing test of linkage applied to the nonmissing families for that SNP. The unadjusted P value for our test is the P value for the test of H₀: the given SNP is the sole cause of linkage, and the adjusted P value is conditional on detection of suggestive evidence for linkage.

^aSNPs implicated in the study by Horikawa et al. (2000).