Table 1.

Articles on High Responders Patients

Article	N	Patients	Groups	Luteal Support	Statistically significant results (p<0.05)
Shapiro B. et al. 2011. USA Retrospective cohort study	273	High Responders	G1) Dual Trigger, G2) Agonist only; G3) Agonist only + intensive luteal support Agonist: Leuprolide acetate. 4mg hCG: 20UI/Kg ( 1000- 2500UI)	E2, 0,2mg/72h + E2 6mg/d + P4, 100mg /d, IM + P4, 800mg/d, VV, beginning 2-5 days after retrieval. Intensive luteal support: beginning immediately after retrieval.	G1: < number of Retrieved Oocytes (20.4±6.2 vs. 27.1±11.2 vs. 25.4±10.3); > Implantation rate (%) (48.8 vs. 20.6 vs. 37.8); > Pregnancy rate (%) (75.3 vs. 60.4 vs. 15); > ongoing pregnancy rate (%) (57.7 vs. 25.3 vs. 50).
O'Neill K.E. et al. 2016, USA Retrospective cohort study	174	High Responders	G1) GnRH agonist: G2) GnRH agonist + hCG Agonist: leuprolide acetate. 4mg hCG: 1000UI	It started on the day after oocyte retrieval: daily IM, 50 mg progesterone 50 mg, IM/day + three 0. 1mg transdermal patches of estradiol, daily	G2: > % oocyte maturity (70% vs. 82%. <% oocytes retrieved (0% vs 3%), > % OHSS (6% vs 0%) and severe OHSS (4% vs. %)
Jung Y.H. et al. 2014. Korea Prospective cohort study	26	High responders	G1) GnRH agonist: G2) GnRH agonist + hCG 1000IU; G3) GnRH agonist + hCG 20001U.	Progesterone (dose: is not described)	G1: < number of retrieved oocytes (4.7±1.5 vs. 10.0±3.7 vs. 20.2±6.8); < pregnancy rate (%) (14,3 vs. 75 vs. 70)
Griffin D. et al. 2012. USA Rctrospcctivc cohort study	102	High Responders	G1) Dual Trigger; G2) GnRHa alone. Agonist: Leuprolide acetate. 1mg hCG: 1000IU	P4, 50mg/d, IM + E2, transdermal, 0,3mg/2d	G1 : < number of embryo frozen (4.3±4.7 vs. 3.6±3.1 ): < Implantation rate (%) (22.1 vs. 41.9); < Pregnancy rate (%) (36.8 vs. 58.8): < live birth rate (%) (30.9 vs. 52.9)
Sherhahn R. 2015. USA Retrospective cohort study	135	Highre sponders	G1)GnRG Agonist; G2) Dual Trigger. hCG: 1500-2000IU. Agonist: Lupron.	P4. IM + E2 Oral or transdcrmal	No statistically significant results.