TABLE 2.
Phytoestrogen concentrations of ENDO study participants and endometriosis status and severity1
| Operative sample |
General sample |
||||||
| Overall | Endometriosis stage I/II | Endometriosis stage III/IV | No endometriosis | Overall | Endometriosis | No endometriosis | |
| n | 494 | 134 | 55 | 283 | 131 | 14 | 113 |
| Isoflavones, nmol/L | |||||||
| Genistein | |||||||
| Unadjusted | 88 (72, 108) | 93 (63, 137) | 94 (58, 152) | 84 (64, 111) | 112 (79, 158) | 86 (28, 271) | 116 (79, 170) |
| Adjusted2 | 88 (72, 108) | 90 (61, 133) | 96 (53, 175) | 86 (65, 112) | 113 (80, 160) | 87 (30, 257) | 116 (79, 170) |
| Daidzein | |||||||
| Unadjusted | 194 (160, 236) | 219 (154, 310) | 149 (84, 266) | 194 (148, 253) | 229 (159, 332) | 182 (59, 561) | 244 (163, 365) |
| Adjusted | 195 (160, 237) | 212 (146, 310) | 151 (85, 270) | 198 (152, 256) | 228 (158, 331) | 188 (61, 578) | 243 (164, 361) |
| O-DMA | |||||||
| Unadjusted | 4 (3, 6) | 5 (2, 9) | 3 (1, 9) | 5 (3, 7) | 7 (4, 14) | 4 (0, 39) | 8 (4, 16) |
| Adjusted | 5 (3, 6) | 4 (2, 8) | 3 (1, 8) | 5 (3, 8) | 7 (4, 13) | 4 (1, 30) | 8 (4, 16) |
| Equol | |||||||
| Unadjusted | 4 (4, 6) | 6 (4, 9)* | 3 (1, 5)* | 4 (3, 6) | 6 (4, 9) | 6 (2, 21) | 6 (4, 10) |
| Adjusted | 5 (4, 6) | 6 (4, 10) | 3 (1, 5) | 4 (3, 6) | 6 (4, 9) | 6 (2, 21) | 6 (4, 10) |
| Total | |||||||
| Unadjusted | 397 (332, 475) | 432 (309, 606) | 332 (199, 553) | 393 (308, 501) | 467 (334, 654) | 320 (108, 948) | 500 (347, 722) |
| Adjusted | 398 (332, 476) | 421 (296, 597) | 335 (196, 573) | 399 (314, 508) | 463 (330, 649) | 330 (118, 924) | 498 (347, 716) |
| Lignan metabolites, nmol/L | |||||||
| Enterodiol | |||||||
| Unadjusted | 29 (22, 38) | 31 (18, 52) | 36 (16, 83) | 27 (19, 38) | 28 (16, 49) | 36 (6, 205) | 28 (16, 52) |
| Adjusted | 28 (21, 37) | 28 (16, 46) | 35 (16, 78) | 28 (19, 40) | 28 (16, 49) | 36 (6, 199) | 28 (16, 52) |
| Enterolactone | |||||||
| Unadjusted | 355 (299, 421) | 399 (288, 553) | 435 (252, 753) | 319 (256, 399) | 464 (340, 635) | 605 (217, 1690) | 455 (323, 639) |
| Adjusted | 352 (297, 418) | 359 (259, 499) | 413 (250, 684) | 334 (267, 419) | 463 (330, 649) | 600 (232, 1550) | 455 (326, 636) |
| Total | |||||||
| Unadjusted | 464 (395, 544) | 536 (400, 719) | 517 (301, 889) | 421 (342, 519) | 573 (423, 777) | 734 (278, 1940) | 562 (403, 784) |
| Adjusted | 460 (392, 540) | 488 (359, 663) | 493 (308, 790) | 438 (355, 541) | 556 (411, 752) | 736 (291, 1860) | 562 (405, 778) |
| Total phytoestrogens | |||||||
| Unadjusted | 1380 (1190, 1590) | 1540 (1200, 1990) | 1340 (873, 2060) | 1310 (1080, 1590) | 1630 (1250, 2120) | 1200 (457, 3130) | 1730 (1300, 2300) |
| Adjusted | 1370 (1190, 1590) | 1450 (1100, 1910) | 1310 (856, 2010) | 1350 (1110, 1630) | 1590 (1220, 2090) | 1220 (534, 2780) | 1720 (1290, 2300) |
1
All values are geometric means (95% CIs) unless otherwise indicated. Values can be converted from nmol/L to ng/mL by dividing by the following conversion factors: genistein, 3.70; daidzein, 3.93; O-DMA, 3.87; equol, 4.13; enterodiol, 3.31; and enterolactone, 3.35. *Different from no endometriosis group, P < 0.05. ENDO, Endometriosis, Natural History, Diagnosis, and Outcomes; O-DMA, O-desmethylangolensin.
2
Adjusted for age and BMI (in kg/m2).