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. 2017 Jan 13;10(1):e003529. doi: 10.1161/CIRCHEARTFAILURE.116.003529

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© 2017 The Authors.

Circulation: Heart Failure is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDervis License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 2. — Network diagram of treatment classes and combinations reporting all-cause mortality. ACEI indicates angiotensin-converting enzyme inhibitor; ARB, angiotensin-II receptor blocker; AREA-IN CHF, Anti-Remodelling Effect of Canrenone in Patients With Mild Chronic Heart Failure; ARNI, angiotensin receptor-neprilysin inhibitor; BB, beta blocker; BEST, Beta-Blocker Evaluation of Survival Trial; CARMEN, The Carvedilol and ACE-Inhibitor Remodelling Mild Heart Failure Evaluation Trial; CASSIS, Czech and Slovak Spirapril Intervention Study; CHARM-added, Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity–Added; CHARM-alternative, Candesartan in Heart Failure–Assessment of Mortality and Morbidity Alternative; CIBIS, Cardiac Insufficiency Bisoprolol Study; CONSENSUS, Cooperative North Scandinavian Enalapril Survival Study; COPERNICUS, Carvedilol Prospective Randomized Cumulative Survival; ELITE, Evaluation of Losartan in the Elderly Study; EMPHASIS-HF, Eplerenone in Mild Patients Hospitalization and Survival Study in Heart Failure; ENECA, Efficacy of Nebivolol in the Treatment of Elderly Patients With Chronic Heart Failure as Add-On Therapy to ACE Inhibitors or Angiotensin II Receptor Blockers, Diuretics, and/or Digitalis; FEST, Fosinopril Efficacy/Safety Trial; HEAVEN, Heart Failure Valsartan Exercise Capacity Evaluation; MERIT-HF, Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure; MHFT, Munich Mild Heart Failure Trial; MIC, Metoprolol in Patients With Mild to Moderate Heart Failure: Effects on Ventricular Function and Cardiopulmonary Exercise Testing; MOCHA, Multicenter Oral Carvedilol Heart Failure Assessment; MRA, mineralocorticoid receptor antagonist; PARADIGM-HF, Prospective Comparison of ARNI (Angiotensin Receptor–Neprilysin Inhibitor) With ACEI (Angiotensin–Converting–Enzyme Inhibitor) to Determine Impact on Global Mortality and Morbidity in Heart Failure; PLBO, placebo; PRECISE, Prospective Randomized Evaluation of Carvedilol on Symptoms and Exercise; RALES, Randomized Aldactone Evaluation Study; REPLACE, Replacement of Angiotensin Converting Enzyme Inhibition; RESOLVD, Randomized Evaluation of Strategies for Left Ventricular Dysfunction; SOLVD-prevent, Studies of Left Ventricular Dysfunction–Prevention Trial; SOLVD-treat, Studies of Left Ventricular Dysfunction–Treatment Trial; SPICE, Study of Patients Intolerant of Converting Enzyme Inhibitors; STRETCH, Symptom, Tolerability, Response to Exercise Trial of Candesartan Cilexetil in Heart Failure; SYMPOXYDEX, Sympathetic and Oxydative Stress Kredex Study; and Val-HeFT, Valsartan Heart Failure Trial.^7,21–77