Figure 3.

Effect of atorvastatin on the insulin content of islets in rats. Fresh isolated rat islets were cultured for 24 hours in the presence of 50 μM atorvastatin. After 24 hours, fresh isolated rat islets were then analyzed by radioimmunoassay (RIA) or further cultured in medium containing Krebs-Ringer bicarbonate buffer for drug elution. The insulin content of the medium was measured before and after the elution by RIA. ^aP < 0.01 versus the control group; ^bP < 0.01 versus the before elution atorvastatin group.