Table 1.
Characteristics of participants in the association of age at menarche and natural menopause
| Study (acronym) | Population | Primary trait | Age at menarche | Age at natural menopause | ||
|---|---|---|---|---|---|---|
| n | Mean (SD) | n | Mean (SD) | |||
| Stage I: Initial Shanghai GWAS meta-analysis | ||||||
| The Shanghai Breast Cancer Study (SBCS) | Chinese | Breast cancer cases | 2697 | 14.5 (1.7) | 821 | 50.0 (3.6) |
| Healthy controlsa | 1987 | 14.7 (1.8) | 684 | 49.1 (4.0) | ||
| The Shanghai Endometrial Cancer Study (SECS) | Chinese | Endometrial cancer cases | 827 | 14.5 (1.7) | 457 | 50.4 (3.4) |
| The Shanghai Type II diabetes Studies (ST2DS) | Chinese | T2D cases | 1030 | 14.7 (1.8) | 496 | 49.3 (3.5) |
| The Shanghai Colorectal Cancer Study (SCRCS) | Chinese | CRC cases | 487 | 15.1 (1.8) | 328 | 49.2 (3.6) |
| Healthy controls | 730 | 15.2 (1.8) | 531 | 49.5 (3.4) | ||
| Other Shanghai cancer studies | Chinese | Other cancer casesb | 315 | 15.3 (1.7) | 239 | 48.9 (3.7) |
| Stage I total | 8073 | 3556 | ||||
| Stage II: replication studies | ||||||
| Nutrition and Health of Aging Population in China (NHAPC) | Chinese | Aging | 1230 | 15.9 (2.1) | 1458 | 48.9 (4.0) |
| The Seoul Breast Cancer Study (SeBCS) | Korean | Breast cancer cases | 2164 | 14.7 (1.7) | 745 | 48.4 (5.5) |
| Healthy controls | 2051 | 15.2 (1.8) | 994 | 49.2 (4.6) | ||
| Shanghai Women’s Health Study (SWHS) | Chinese | Healthy womenc | 2877 | 15.1 (1.8) | 1911 | 49.0 (4.1) |
| Stage II total | 8322 | 5108 | ||||
| Stage I and II total | 16,395 | 8664 | ||||
aNote shared controls in GWAS in Stage I; most samples were selected from the Shanghai Women’s Health Study (Zheng et al., 2005)
bThese include 219 cases from the Shanghai Upper Gastrointestinal Cancer Study (SUGICS), 46 cases from the Shanghai Pancreatic Cancer Study (SPCS), and 50 cases with other cancers
cNot included in Stage I GWAS, with genotype data available for several genetic variants noted in Table 2