Fig. 3.

Temporal relationship between Avid and temperature. a–b Total Avid observed in wild-type (a) and hif-1 (b) worms who started their lifespans at 25 °C and were transferred to 15 °C at progressively later times during their life. c–d Avid observed in wild-type (c) and hif-1 (d) worms who started their lifespans at 15 °C and were transferred to 25 °C at progressively later times during their life. e Model for the time frame when Avid levels can be modified by changing temperature. For a–d, the stage of life where temperature was changed is noted (L = larval, YA = young adult, RA = reproductive adult, LR = late reproductive adult, PR = post-reproductive adult)