Fig. 6.

Interventions that increase longevity prevent Avid. a Average Avid levels of control N2 worms and hif-1(ia4) worms in fed and dietary restriction (DR) conditions. b Avid levels of various germline mutants in fed and DR conditions. c–d Fraction of worms with Avid over their lifetime when removed from food at different times during adulthood. e Lifespans of wild-type (N2) worms and hif-1(ia4) worms in fed and bacterial deprivation conditions. f Average Avid levels of wild-type and daf-2(RNAi) worms at 15 °C and 20°. g Model describing how increased lifespan and reduced healthspan are commonly observed together. All bars represent the average of all experiments at the given temperature. All error bars represent standard error of the mean, asterisk represents p value <0.05 by paired t test