Table 2.

Moderated moderation analysis with the MMSE score as a dependent variable and age, the APOE ε4 allele, education, and three interactions as independent variables (Analysis 1)

	B	SE	t value	p value	Lower LCI	Upper LCI
Constant	123.56	11.83	10.44	0.00	100.30	146.82
Age	−1.10	0.11	−9.63	0.00	−1.33	−0.88
APOE	−4.27	1.37	−3.12	0.00	−6.96	−1.58
Education	1.21	0.52	2.35	0.02	0.19	2.23
Gender	−3.78	1.06	−3.56	0.00	−5.86	−1.69
APOE × education	0.29	1.65	0.17	0.86	−2.95	3.53
APOE × gender	5.30	5.33	0.99	0.32	−5.18	15.78
Education × gender	−0.87	1.12	−0.78	0.044	−3.08	1.34
APOE × education × gender	12.76	5.63	2.27	0.02	1.69	23.83
Conditional effect of APOE × education at values of gender
Gender	Effect	SE	t value	p value	Lower LCI	Upper LCI
Man	−10.38	5.38	−1.93	0.05	−20.96	0.19
Woman	2.38	1.67	1.43	0.15	−0.90	5.65

Note: The variables, APOE, gender, and education were mean-centered prior to analysis. Gender: man = 1, woman = 2; APOE ε4 allele: the ε4 noncarriers = 0, the ε4 carriers = 1; education: low = 1, middle = 2, high = 3