Table 3.

Moderated moderation analysis with the MMSE score as a dependent variable and age, the APOE ε4 allele, education, and three interactions as independent variables (Analysis 2)

		B	SE	t value	p value	Lower LCI	Upper LCI
Constant		127.09	11.62	10.94	0.00	104.25	149.93
Age		−1.13	0.11	−10.11	0.00	−1.36	−0.91
APOE		−3.55	1.50	−2.37	0.02	−6.50	−0.61
Education		1.68	1.10	1.53	0.13	−0.48	3.84
Gender		−3.71	1.17	−3.17	0.00	−6.00	−1.41
APOE × education		3.10	3.24	0.96	0.34	−3.27	9.46
APOE × gender		1.30	6.52	0.20	0.84	−11.51	14.11
Education × gender		−1.97	2.22	−0.89	0.38	−6.32	2.39
APOE × education × gender		27.80	9.96	2.79	0.01	8.24	47.37
Conditional effect of APOE x education at values of gender
Gender		Effect	SE	t value	p value	Lower LCI	Upper LCI
Man		−20.15	9.35	−2.15	0.03	−38.54	−1.77
Woman		7.65	3.41	2.24	0.03	0.94	14.35
Conditional effect of APOE on the MMSE at values of gender x education
Gender	Education	Effect	SE	t value	p value	Lower LCI	Upper LCI
Man	Low	−1.26	7.60	−0.17	0.87	−16.19	13.68
Man	High	−21.41	5.47	−3.91	0.00	−32.16	−10.66
Woman	Low	−4.63	1.41	−3.27	0.00	−7.40	−1.85
Woman	High	3.02	3.11	0.97	0.33	−3.08	9.12

The variables, APOE, gender, and education were mean-centered prior to analysis. Gender: man = 1, woman = 2; APOE ε4 allele: the ε4 noncarriers = 0, the ε4 carriers = 1; education: low = 1, high = 2