Table 6.
Necropsy results for the ramipril-treated and control mice shown in Fig. 1c
| Organ | Pathology | Dietary treatment | ||||
|---|---|---|---|---|---|---|
| Control (n = 36)a | Ramipril (n = 36) | |||||
| No.b | (%)c | No. | (%) | P valued | ||
| Spleen | Enlarged/tumorous | 19 | 70.4 | 16 | 59.3 | 0.569 |
| Liver | Hemangioma | 0 | 0.0 | 0 | 0.0 | 1.000 |
| Enlarged/fatty liver | 1 | 3.7 | 1 | 3.7 | 1.000 | |
| Tumor | 18 | 66.7 | 11 | 40.7 | 0.101 | |
| Intestine | Tumor | 2 | 7.4 | 1 | 3.7 | 1.000 |
| Lung | Tumor | 19 | 70.4 | 12 | 44.4 | 0.098 |
| Penis | Necrosed/inflamed | 0 | 0.0 | 1 | 3.7 | 1.000 |
| Seminal vesicle | Enlarged | 2 | 7.4 | 1 | 3.7 | 1.000 |
| Bladder | Distended | 1 | 3.7 | 1 | 3.7 | 1.000 |
| Kidney | Enlarged/tumorous | 2 | 7.4 | 1 | 3.7 | 1.000 |
| Thymus | Enlarged | 5 | 18.5 | 7 | 25.9 | 0.7445 |
| Skin/abdominal cavity | Fibroma | 4 | 14.8 | 6 | 22.2 | 0.7277 |
| Body cavity | Hemorrhage | 7 | 25.9 | 9 | 33.3 | 0.7664 |
| Thorax only | Hemorrhage | 8 | 29.6 | 3 | 11.1 | 0.1751 |
| Body cavity and thorax | Hemorrhage | 15 | 55.6 | 12 | 44.4 | 0.5867 |
aNumber of necropsied mice in each group. All deceased mice were necropsied. The necropsied control mice were chosen to approximate the ages at death of the ramipril-treated mice
bThe number of necropsied mice with each pathology
cThe percent of the necropsied mice in each group with the indicated pathologies
dFisher’s exact test was utilized to investigate the association between the pathologies and ramipril treatment. The P values are two-sided. No significant differences were found