Table 3.
Multivariate Cox regression modeling of incident Alzheimer’s disease (n = 158). Hazard ratios (HR) and p values of random effects meta-analyses of FINRISK 1997 and 2002 cohorts are presented
| Variable | HR (95% CI), random | p* | |
|---|---|---|---|
| Multivariate model without Apo A-I, HDL-C, or Apo B in the model | Sex (for female gender) | 1.16 (0.84–1.61) | 0.370 |
| Age (per quantile step) | 9.72 (6.37–14.84) | <0.001 | |
| log—Total cholesterol (per 1SD) | 0.90 (0.76–1.07) | 0.233 | |
| log—Systolic blood pressure (per 1SD) | 0.91 (0.77–1.08) | 0.282 | |
| log Body mass index (per 1SD) | 0.70 (0.59–0.85) | <0.001 | |
| Education (per year) | 0.95 (0.86–1.04) | 0.243 | |
| ApoE (number of risk ɛ4 alleles) | 3.24 (2.57–4.09) | <0.001 | |
| Analyzed separately of each other and adjusted for all variables above | log Apolipoprotein A-I (per 1SD) | 0.83 (0.69–1.01) | 0.057 |
| log—HDL cholesterol (per 1SD) | 0.84 (0.66–1.07) | 0.166 | |
| log Apolipoprotein B (per 1SD)a | 0.93 (0.77–1.11) | 0.418 | |
| log Apolipoprotein B/A (per 1SD)a | 1.08 (0.89–1.31) | 0.430 | |
| Analyzed separately of each other and adjusted for all variables above except for apo E genotype | log Apolipoprotein A-I (per 1SD) | 0.77 (0.65–0.92) | 0.005 |
| log—HDL cholesterol (per 1SD) | 0.79 (0.61–1.03) | 0.087 | |
| log Apolipoprotein B (per 1SD)a | 1.05 (0.88–1.27) | 0.584 | |
| log Apolipoprotein B/A (per 1SD)a | 1.22 (1.01–1.48) | 0.040 |
Total cholesterol, HDL cholesterol, systolic blood pressure, body mass index, apolipoprotein A-I, apolipoprotein B, and apolipoprotein B/A ratio were log-transformed before multivariate analysis
aIn the model without total cholesterol
apo A-I apolipoprotein A-I, HDL-C high density lipoprotein cholesterol, apo B apolipoprotein B, apo B/A ratio ratio between apolipoprotein B and apolipoprotein A-I