Table 1. Blood variables, atherosclerosis and gene expression in aorta of lean and obese mice.

	C57BL/6J	LDLR-/-	Ob/Ob	DKO	ANOVA
	N = 10	N = 8	N = 10	N = 12
A. Weight and blood variables
Gender (male, n)	5	4	5	6
Weight (g)	27±4.4	26±5.0	68±3.5***/†††	63±3.3**/†	P<0.001
ADN (μg/mL)	5.5±1.9	4.0±1.0	4.7±0.9	2.8±1.7**/‡	P<0.01
Glucose (mg/dL)	76±12	77±6.8	117±24**/††	136±45***/†††	P<0.001
IPGTT a	35±1.5	49±7.3	56±12**	84±25***/†	P<0.001
Insulin (mU/L)	72±15	51±17	94±60	181±76**/†††/‡	P<0.001
HOMA-IR	1.4±0.35	0.96±0.31	2.7±1.6	6.6±4.1**/†††	P<0.001
Total C (mg/dL)	54±13	155±44**	63±22	467±89***/‡‡‡	P<0.001
TG (mg/dL)	43±16	45±20	28±4.9	196±45**/††/‡‡‡	P<0.001
B. Atherosclerosis
Plaque volume b	ND	19±15	ND	87±22†††	- -
MQ (%)	ND	21±11	ND	28±11	- -
Oxidized LDL (%)	ND	5.0±3.0	ND	12±5.0††	- -
SMC (%)	ND	5.0±5.2	ND	8.2±6.2	- -
C. Gene expressions in aorta
Mt-co1	1.05±0.36	2.63±1.23	1.07±0.25††	0.54±0.18*/†††/‡‡	P<0.001
Tfam	1.02±0.21	1.04±0.45	0.88±0.26	0.63±0.13*	P<0.001
Cox4i1	1.06±0.35	0.91±0.47	0.47±0.04***/†	0.64±0.16*	P<0.001
Cox10	1.06±0.36	1.13±0.55	0.70±0.15*	0.82±0.18	P<0.01
Mcp1-to-Cd206 ratio	ND	1.00±0.24	ND	3.86±1.16†††	- -

Data shown are means ± SD. Abbreviations: ADN: adiponectin; AUC: area under curve; C: cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; IPGTT: intraperitoneal glucose tolerance test; MQ: SMC: smooth muscle cells; TG: triglyceride. ^a Area under curve x 10³; ^b total plaque volumes were expressed in x 10⁻³ μm³, measured on Oil Red O stained sections. ND: detectable. Because C57BL6 and ob/ob mice did not have atherosclerotic plaques; ANOVA was not performed.

^*P < 0.05

^**P < 0.01 and

^***P < 0.001 compared with C57BL/6J;

^†P < 0.05

^††P < 0.01

^†††P < 0.001 compared with LDLR^(-/-);

^‡P < 0.05

^‡‡P < 0.01

^‡‡‡P < 0.001 compared with ob/ob.