Table 2. Effect of caloric restriction in DKO mice.
| Placebo | Caloric restriction | |
|---|---|---|
| N = 12 | N = 10 | |
| Gender (male, n) | 6 | 5 |
| Weight (g) | 63±3.3 | 35±5.0*** |
| ADN (μg/mL) | 2.8±1.7 | 5.8±1.3** |
| Glucose (mg/dL) | 136±45 | 158±60 |
| IPGTTa | 84±25 | 84±26 |
| Insulin (mU/L) | 181±76 | 101±51* |
| HOMA-IR | 6.6±4.1 | 3.1±1.9* |
| Total C (mg/dL) | 467±89 | 393±66* |
| TG (mg/dL) | 196±45 | 103±45*** |
| Titer Abs OxLDL | 9.34±1.66 | 6.40±0.77*** |
| B. Atherosclerosis | ||
| Plaque volume b | 87±22 | 31±10*** |
| MQ (%) | 28±11 | 22±5.0 |
| OxLDL (%) | 12±5.0 | 3.9±0.77*** |
| SMC (%) | 8.2±6.2 | 8.9±2.1 |
Data shown are means ± SD. Abbreviations: Abs; antibodies; ADN: adiponectin; C: cholesterol; HOMA-IR, homeostasis model assessment of insulin resistance; IPGTT: intraperitoneal glucose tolerance test; MQ: macrophages; OxLDL: oxidized LDL; SMC: smooth muscle cells; TG: triglyceride.
*P < 0.05
**P < 0.01
***P < 0.001 compared with control DKO
a Area under curve x 103
b total plaque volumes were expressed in x 10−3 μm³, measured on Oil Red O stained sections.