Fig 3. Canonical Discriminate functions of CKCS with and without CM pain and SM.Hindbrain study.

Average 64.6% correctly classified with SM affected highest separation of 78.9%. Function 1 increases with larger angles 5, 7 and 9 and Function 2 increased with larger angles 5 and 7 but smaller angle 9. Thus, SM cohort has smaller angles 5, 7 and 9 than other groups because the centroid is furthest on the left. The CM pain cohort on average has larger angles 7 and 9. The Control cohort has highest centroid in Function 2 hence they would, on average, they have larger angles 5 and 7 and smaller angle 9. Whole brain study: Average 72.5% of the group was correctly classified with 93.3% of Control cohort. Function 1 the combined effect of decreases with of ellipticity and angle 2 (fac) but increases with lines bk, the n-diameter and the olfactory bulb angle. Function 2 increases with line bk, ellipticity and olfactory bulb and decreases with angle 2 and the n-diameter. It follows that the group has the centroid on the left side and has a more elliptic brain, wider angle 2 but smaller olfactory bulb angle (i.e. the olfactory bulb is not so rotated).