Table 4. Associations between CD4/CD8 ratio categories (relative to ratio>1.0) with DLCO and FEV1 in linear regression models.

Outcome	CD4/CD8<0.4	CD4/CD8 0.4–1.0
DLCO %-predicteda Unadjusted model Adjusted modelb Adjusted model plus CD4 and HIV viral loadc Adjusted model plus CD4, HIV viral load, nadir CD4 and sCD14d	-11% (-17%, -4.5%)* -8.7% (-14%, -3.1%)* -8.7% (-14%, -2.9%)* -9.0% (-17%, -1.4%)*	-5.5% (-12%, 0.7%) -5.0% (-10%, 0.36%) -5.0% (-10%, 0.47%) -5.7% (-12, 0.67)
FEV1%-predicteda Unadjusted model Adjusted modelb Adjusted model plus CD4 and HIV viral loadc	-5.1% (-13%, 3.1%) -7.4% (-16%, 1.0%) -3.4% (-14%, 6.7%)	-3.1% (-11%, 4.9%) -5.1% (-13%, 2.9%) -3.7% (-12.%, 4.7%)

^aEstimate of difference in %-predicted values (95% CI) for CD4/CD8 ratios relative to ratio >1.0

^bModel adjusted for age, sex, race/ethnicity, BMI, pack-years of tobacco use, chronic diseases (chronic heart disease, anemia, diabetes, hypertension) and inhalational and intravenous drug use

^cAdjusted model with additional inclusion of CD4 cell count and viral load

^dAdjusted model with additional inclusion of CD4 cell count, viral load, nadir CD4 and soluble CD14

*P<0.05

DLCO = diffusion capacity of carbon monoxide, FEV1 = forced expiratory volume in 1 second