Table 1.

Change of body weight and hepatotoxicity parameters after oral administration of saccharin for 7 consecutive days to male ICR mice

Dose (mg/kg)	Body weight (g)	Liver weight (g)	ALT (Karmen)	GSH (%)
0	31.7 ± 0.6	1.9 ± 0.1	105.6 ± 7.0	100.0 ± 12.0
250	33.5 ± 1.6	1.9 ± 0.2	123.1 ± 8.7	121.4 ± 8.8
1000	32.9 ± 0.5	1.9 ± 0.1	135.7 ± 36.0	94.5 ± 5.7
4000	33.0 ± 0.6	2.1 ± 0.0*	129.6 ± 22.4	122.6 ± 1.9

Male ICR mice were treated orally with 250, 1,000, and 4,000mg/kg of saccharin in saline for 7 days. Animals were subjected to necropsy 24 hr after the last treatment. Each value represents the mean ± standard error (SE) of 3~5 animals. The asterisks indicate the values significantly different from the control at either P< 0.05 (*).