Table 2.
Plasma concentration-time curve of bupropion after pretreatment with saccharin (4,000 mg/kg) for 7 days and after concomitant administration of saccharin and bupropion to male ICR mice
| Saccharin (mg/kg) | Pharmacokinetic parameters | ||||
|---|---|---|---|---|---|
|
| |||||
| Tmax (min) | Cmax (mg/mL) | AUC (mg · min/mL) | T1/2 (min) | ||
| 7 Days pretreatment | 0 | 30.0 ± 21.2 | 0.4 ± 0.1 | 50.1 ± 13.6 | 110.3 ± 26.9 |
| 4,000 | 13.3 ± 2.4 | 0.6 ± 0.1 | 66.2 ± 11.6 | 77.6 ± 4.9 | |
|
| |||||
| Single co-treatment | 0 | 15.0 ± 0.0 | 0.7 ± 0.2 | 81.9 ± 11.6 | 68.3 ± 18.7 |
| 4,000 | 20.0 ± 7.1 | 0.6 ± 0.2 | 68.5 ± 4.2 | 112.9 ± 81.2 | |
Male ICR mice were treated orally with 0 and 4,000mg/kg of saccharin in water for 7 consecutive or received a single oral administration. Each value represents the mean ± standard error (SE) of 3~5 animals.