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Toxic effects of adjuvant chemotherapy in terms of leukopenia (A), diarrhea (B), chemotherapy regimen-specific toxicities (C) (rash for S-1 in ACTS-GC study, and neuropathy for XELOX in CLASSIC study), thrombocytopenia (D), vomiting (E), and fatigue (F). Risk ratios were analyzed with random effects model. Value 0-1 favors adjuvant chemotherapy. CI, confidence interval; CTX, chemotherapy; XELOX, capecitabine plus oxaliplatin.
