Table 2.
Univariable and multivariable analysis of factors prognostic of 5-year DFS after pulmonary metastasectomy
| Characteristic | No. (n=122) | 5-Yr DFS (%) | p-value | HR | 95% CI | p-value |
|---|---|---|---|---|---|---|
| Age (yr) | ||||||
| ≤ 60 | 55 | 49.4 | 0.23 | - | - | |
| > 60 | 67 | 50.0 | - | - | ||
| Sex | ||||||
| Male | 83 | 48.3 | 0.67 | - | - | |
| Female | 39 | 57.7 | - | - | ||
| Body mass index (kg/m2) | ||||||
| ≤ 25 | 88 | 60.5 | 0.99 | - | - | |
| < 25 | 34 | 55.7 | - | - | ||
| Primary tumor location | ||||||
| Colon | 55 | 48.4 | > 0.99 | - | - | |
| Rectum | 67 | 53.2 | - | - | ||
| Tumor stagea) | ||||||
| 1 | 5 | 66.7 | 0.08 | - | - | |
| 2 | 24 | 74.3 | - | |||
| 3 | 72 | 49.4 | - | |||
| 4 | 21 | 29.9 | - | - | ||
| Histology of primary tumor | ||||||
| Well differentiated | 12 | 37.3 | 0.89 | - | - | |
| Moderately differentiated | 105 | 52.8 | - | |||
| Mucinous or poorly differentiated | 5 | 53.3 | - | - | ||
| Previous hepatectomy | ||||||
| No | 108 | 53.8 | 0.12 | - | - | |
| Yes | 14 | 23.4 | - | - | ||
| Adjuvant therapy for CRC | ||||||
| No | 5 | 100 | 0.10 | - | - | |
| Yes | 117 | 49.0 | - | - | ||
| Disease-free interval (mo) | ||||||
| < 12 | 21 | 25.8 | 0.01 | 1 | 0.01 | |
| ≥ 12 | 101 | 55.8 | 0.298 | 0.149-0.598 | ||
| No. of pulmonary tumors | ||||||
| Solitary | 77 | 60.9 | 0.01 | 1 | 0.01 | |
| Multiple | 45 | 34.4 | 2.451 | 1.285-4.674 | ||
| Maximal tumor size (mm) | ||||||
| ≤ 20 | 106 | 52.8 | 0.12 | - | - | |
| > 20 | 16 | 39.0 | - | - | ||
| Distribution of metastases | ||||||
| Unilateral | 108 | 54.5 | 0.01 | 1 | 0.97 | |
| Bilateral | 14 | 23.8 | 1.014 | 0.418-2.463 | ||
| Resectionb) | ||||||
| Non-anatomical | 90 | 50.1 | 0.79 | - | - | |
| Anatomical | 32 | 52.9 | - | - | ||
| Mediastinal LN dissection | ||||||
| No | 70 | 50.2 | 0.62 | - | - | |
| Yes | 52 | 50.8 | - | - | ||
| Mediastinal LN involvement | ||||||
| No | 44 | 58.6 | 0.01 | 1 | 0.01 | |
| Yes | 8 | 0.0 | 6.048 | 2.099-17.427 | 0.01 | |
| No data | 70 | 50.2 | 1.014 | 0.418-2.463 | 0.58 | |
| Chemotherapy after PM | ||||||
| No | 11 | 68.2 | 0.58 | - | - | |
| Cytotoxic agent only | 97 | 58.0 | - | |||
| Cytotoxic agent+targeted agent | 14 | 60.0 | - | - |
DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; CRC, colorectal cancer; LN, lymph node; PM, pulmonary metastasectomy.
a)
Using the seventh edition of the American Joint Committee on Cancer staging system,
b)
Non-anatomical resection included precision excision and wedge resection; anatomical resection included segmental resection and lobectomy.