Table 1.
Rates of change in imaging parameters compared with the development of AD
| Imaging parameter | Whole group, n = 149 (mean ± SD) | No AD, n = 139 (mean ± SD) | AD, n = 10 (mean ± SD) | Unadjusted 2-sample t test P-value between AD and no-AD groups | ROC AUC for identifying those with AD (95% CI) |
|---|---|---|---|---|---|
| Scheltens' score at age 68.6 ± 0.6 y | 0.05 ± 0.18 | 0.04 ± 0.16 | 0.25 ± 0.35 | .089 | 0.67 (0.51–0.83) |
| Scheltens' score at age 72.8 ± 0.5 y | 0.11 ± 0.33 | 0.08 ± 0.25 | 0.65 ± 0.67 | .023 | 0.76 (0.60–0.93) |
| ΔScheltens' score/Δt, arbitrary units/y | 0.02 ± 0.07 | 0.010 ± 0.057 | 0.092 ± 0.179 | .162 | 0.67 (0.46–0.87) |
| Rounding ratio at age 68.6 ± 0.6 y | 0.66 ± 0.10 | 0.68 ± 0.11 | 0.68 ± 0.06 | .819 | 0.52 (0.39–0.65) |
| Rounding ratio at age 72.8 ± 0.5 y | 0.67 ± 010 | 0.67 ± 0.10 | 0.67 ± 0.11 | .857 | 0.53 (0.32–0.74) |
| ΔRounding ratio/Δt, no units/y | −0.98 ± 20.6 ×10−3 | −0.81 ± 20.0 ×10−3 | −3.42 ± 28.7 ×10−3 | .783 | 0.61 (0.42–0.80) |
| Volume mm3 at age 68.6 ± 0.6 y | 4157 ± 433 | 4194 ± 413 | 3647 ± 407 | .002** | 0.84 (0.70–0.98) |
| Volume mm3 at age 72.8 ± 0.5 y | 3983 ± 476 | 4046 ± 418 | 3116 ± 385 | <.001**** | 0.95 (0.89–1.00) |
| ΔVolume/Δt, mm3/y | −41.7 ± 46.3 | −35.6 ± 38.5 | −126.1 ± 63.8 | .001** | 0.90 (0.78–1.00) |
| Hippocampal fraction at age 68.6 ± 0.6 y | 2.75 ± 0.27 ×10−3 | 2.77 ± 0.27 ×10−3 | 2.52 ± 0.30 ×10−3 | .030* | 0.73 (0.58–0.88) |
| Hippocampal fraction at age 72.8 ± 0.5 y | 2.64 ± 0.31 ×10−3 | 2.67 ± 0.29 ×10−3 | 2.17 ± 0.29 ×10−3 | .001** | 0.89 (0.81–0.98) |
| Hippocampal fraction/Δt, per y | −2.77 ± 3.41 ×10−5 | −2.35 ± 2.95 ×10−5 | −8.55 ± 4.17 ×10−5 | .001** | 0.91 (0.79–1.00) |
Abbreviations: AD, Alzheimer's dementia; SD, standard deviation; ROC, receiver operating characteristic; AUC, area under the curve; CI, confidence interval.